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Rescuing IOC with amlodipine in the animal model As an L-type Ca 2+ channel blocker, amlodipine can reduce the entry of non-transferrin-bound iron (Fe 2+ ) via L-type Ca 2+ channels, resulting in lower levels of cardiac iron and reduced oxidative stress in cardiac tissue

The study suggests that ASAH2 controls the basal activation of AKT, a major pathway employed by MDSCs to drive immunosuppressive phenotypes, making it a potential checkpoint for colon cancer treatment

[DOI] [PubMed] [Google Scholar] 110.Soeda J., Mouralidarane A., Ray S